Most of the rockets and ballistic missiles were shot down, but several impacted al-Asad airbase.
The strike followed Houthi attack on a merchant vessel Monday.
Houthi rebels launched an attack Friday morning after a U.S.-U.K. strike on more than 60 targets in Yemen.
The services have newly confirmed leaders heading into 2024.
Cmdr. William Coulter was relieved due to “a loss of confidence in his ability to command," the Navy said Thursday.
The four-day break has been the longest since steady attacks began on Oct. 17.
Thursday's intercept was the second time the warship had shot down drones in eight days.
The number of attacks on U.S. troops in the Middle East has risen to 66.
Apart from defeating torpedoes with torpedoes (yes, you read that right), the Navy is also improving its safety gear.
Roughly half of the reported injuries are traumatic brain injuries.
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